Holyheads latest league outing at Eithin Duon last Saturday saw them start like an express train, scoring four times inside the first 25 minutes - as well as miss a penalty in that golden spell.
Pictures from the match
Although Llanrug hit back twice, they were unable to stave off a fifth successive defeat this term at the hands of the Anglesey side.
United started well enough with Rhys Roberts setting up Carl Griffiths who forced a fine save from Hotspur keeper Ben Heald in the first minute.
However, Hotspur were soon at their scintillating best, making the breakthrough on seven minutes when Gareth Owen headed the ball down and Kenleigh Owen scored with an unstoppable shot.
A minute later it was 2-0, Jay Gibbs hitting the underside of the bar before the ball came to Mike Edwards who fed it back into the danger area and this time Gibbs made no mistake, heading home powerfully.
It was 3-0 on 13 minutes, Gibbs heading in again from an Edwards corner for his 22nd goal for the team this season and in the 17th minute the unstoppable Gibbs had a golden chance for a hat-trick.
Owen was brought down in the area and Gibbs took the penalty, but Dave Ball saved.
Nonetheless, the fourth goal arrived after 25 minutes when Mel McGinness leapt like a salmon to head home Richie Owens free-kick and notch his 45th of the season.
McGinness just failed to get on the end of a cross and Luke John Roberts back-header forced Ball to tip over before the Caernarfon area side pulled one back on 39 minutes, Gruff Williams setting up Kevin Lloyd to score with a deft flick.
Five minutes into the second stanza David Noel Williams free-kick to the back post was met by a Lloyd looping header which dropped inside the other upright to make it 4-2.
That was as close as Llanrug were to get, however, and Gibbs so nearly completed a treble when he rattled the post in the closing stages.
Before the match a minute silence was held in honour of the late Colin Williams, father of Hotspur player Curt, who passed away last week.